Designing the next generation of gene therapy treatments

GFP expression in the retinal vasculature The Ocular Gene Therapy Laboratory (OGTL) founded by Daniel M. Lipinski, DPhil, is dedicated to the development of novel therapies to prevent human blindness. Occupying >1,000 sq.ft. of research space within the Medical College of Wisconsin Eye Institute, OGTL provides the expertise and infrastructure to design the next generation of gene therapy treatments aimed at preventing retinal cell death or dysfunction.
OGTL News
Emily Nettescheim
October 5, 2018

Farewell– Emily Nettesheim heads to industry

Emily Nettesheim, a research technologist within the OGTL, leaves today to pursue an exciting opportunity at Tenaya Therapeutics.
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Scientific Reports
September 21, 2018

Grant – National Eye Institute

Dr Daniel Lipinski and the Ocular Gene Therapy Laboratory have been awarded a Research Project Grant (R01) from the National Eye Institute entitled ‘Vascular gene delivery and early disease biomarkers in diabetic retinopathy’.
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Robert A. Brandt Macular Degeneration Fund
June 12, 2018

Congratulations – Dwani Patel receives Vision Research Trainee Grant.

The McPherson Eye Research Institute announced today that Dwani Patel, a second year PhD student in the OGTL, has been awarded one of only two Vision Research Trainee Grants for 2018.
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Key Publications

Reid CA, Nettesheim, E.R., Connor, T.B., Lipinski DM.  Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD   Sci Rep   8(1):11763 (2018).

 
 
 

Reid CA, Ertel KJ, Lipinski DM.   Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors.   Invest Ophthalmol Vis Sci.   2017 12 01;58(14):6429-6439.

 
 
 

Lipinski DM, Barnard AR, Singh MS, Martin C, Lee EJ, Davies WIL, MacLaren RE.   CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa.   Mol Ther.   2015 Aug;23(8):1308-1319.

 
 
 

Singh MS, Charbel Issa P, Butler R, Martin C, Lipinski DM, Sekaran S, Barnard AR, MacLaren RE.   Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.   Proc Natl Acad Sci U S A.   2013 Jan 15;110(3):1101-6.

 

Histology - retinal layers

Upcoming Events
November 7, 2018 Alexandra Harrington, MD
“Transforming faculty in MCW's Kern Institute: where are we and where do we need to go?”
Grand Rounds
Ophthalmology and Visual Sciences
Medical College of Wisconsin
Milwaukee, WI, USA
December 5, 2018 Arsham Sheybani, MD
“Learning about physiology through MIGS”
Grand Rounds
Ophthalmology and Visual Sciences
Medical College of Wisconsin
Milwaukee, WI, USA
December 7, 2018 John Flannery, PhD
“Engineering viral gene therapies for retinal degenerations”
Vision Science Distinguished Lecture Series
Ophthalmology and Visual Sciences
Medical College of Wisconsin
Milwaukee, WI, USA
December 11, 2018 Daniel Lipinski, M.Sc., D.Phil.
“Developing a gene therapy for diabetic retinopathy”
McPherson Eye Research Institute Seminar Series
University of Wisconsin, Madison, WI
January 7, 2019 Ching-Kang Jason Chen, PhD
“Mechanisms, function and utility of neuronal oscillation in deafferentated retinas”
Vision Science Distinguished Lecture Series
Ophthalmology and Visual Sciences
Medical College of Wisconsin
Milwaukee, WI, USA
February 4, 2019 Mandeep Singh, MD, PhD
“Mechanisms of photoreceptor transplantation”
Vision Science Distinguished Lecture Series
Ophthalmology and Visual Sciences
Medical College of Wisconsin
March 25, 2019 Neena Haider, PhD
“Gene identification to gene therapy: development of the first broad spectrum therapy for inherited retinal disease”
Vision Science Distinguished Lecture Series
Ophthalmology and Visual Sciences
Medical College of Wisconsin
Milwaukee, WI, USA

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