Designing the next generation of gene therapy treatments

GFP expression in the retinal vasculature The Ocular Gene Therapy Laboratory (OGTL) founded by Daniel M. Lipinski, DPhil, is dedicated to the development of novel therapies to prevent human blindness. Occupying >1,000 sq.ft. of research space within the Medical College of Wisconsin Eye Institute, OGTL provides the expertise and infrastructure to design the next generation of gene therapy treatments aimed at preventing retinal cell death or dysfunction.
OGTL News
OGTL collaborative research
June 11, 2019

Publication – OGTL collaborative research is published in Cell reports

In collaboration with Dr Ron Gregg, Study leader and Professor of Biochemistry at the University of Louisville, OGTL researchers helped explore the synaptic connectivity between rod photoreceptors and depolarizing bipolar cells.
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Dwani Patel
April 16, 2019

Congratulations - Dwani Patel accepted to Cold Spring Harbor Laboratory

Dwani Patel, a second year MD-PhD student, has been accepted as a student on a prestigious course at the Cold Spring Harbor Laboratory entitled ‘Vision: a platform for linking circuits, behaviour & perception’.
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Erika Shaw
February 06, 2019

Welcome – Erika Shaw joins the OGTL as a graduate student

Erika Shaw, a first year graduate student in the Neuroscience Doctoral Program (NDP), has elected to join the Lipinski Laboratory full time to complete her graduate studies.
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Key Publications

Reid CA, Nettesheim, E.R., Connor, T.B., Lipinski DM.  Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD   Sci Rep   8(1):11763 (2018).

 
 
 

Reid CA, Ertel KJ, Lipinski DM.   Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors.   Invest Ophthalmol Vis Sci.   2017 12 01;58(14):6429-6439.

 
 
 

Lipinski DM, Barnard AR, Singh MS, Martin C, Lee EJ, Davies WIL, MacLaren RE.   CNTF Gene Therapy Confers Lifelong Neuroprotection in a Mouse Model of Human Retinitis Pigmentosa.   Mol Ther.   2015 Aug;23(8):1308-1319.

 
 
 

Singh MS, Charbel Issa P, Butler R, Martin C, Lipinski DM, Sekaran S, Barnard AR, MacLaren RE.   Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.   Proc Natl Acad Sci U S A.   2013 Jan 15;110(3):1101-6.

 

Histology - retinal layers

Upcoming Events
September 4, 2019 Prem Subramanian, MD, PhD
“The Eye and Vision in Microgravity”
Department of Ophthalmology Grand Rounds
Medical College of Wisconsin, Milwaukee, WI
September 26, 2019 Deepak Lamba, PhD
“Stem Cell-Based Repair and Disease Modeling”
Distinguished Lecture Series
Medical College of Wisconsin, Milwaukee, WI
October 2, 2019 Michael Chiang, MD
“Informatics and Big Data for Eye Care: Promises, Challenges, Solutions”
Department of Ophthalmology Grand Rounds
Medical College of Wisconsin, Milwaukee, WI
October 28, 2019 James B Hurley, PhD
“Engineering Viral Gene Therapies for Retinal Degenerations”
Distinguished Lecture Series
Medical College of Wisconsin, Milwaukee, WI
November 6, 2019 Neda Esmaili, MD
“Faculty Development in the Department of Ophthalmology”
Department of Ophthalmology Grand Rounds
Medical College of Wisconsin, Milwaukee, WI
November 18, 2019 Christine A. Curcio, PhDJames B Hurley, PhD
“Timelines Of Age‐Related Macular Degeneration On Clinical, Lifespan, and Evolutionary Scales”
Distinguished Lecture Series
Medical College of Wisconsin, Milwaukee, WI
December 4, 2019 Iris Kassem, MD
“Ocular Findings in Fabry Disease: More than Just Cornea Verticillata”
Department of Ophthalmology Grand Rounds
Medical College of Wisconsin, Milwaukee, WI
December 9, 2019 Simon Peterson-Jones, Dvet MED, PhD, DECVO
“Advancing Understanding and Therapy for Retinal Dystrophies With Spontaneous Large Animal Models”
Distinguished Lecture Series
Medical College of Wisconsin, Milwaukee, WI
January 27, 2020 Goldis Malek, PhD
“Nuclear Receptors: Therapeutics Targets for Age-Related Macular Degeneration?”
Distinguished Lecture Series
Medical College of Wisconsin, Milwaukee, WI
March 30, 2020 Geoffrey Aguirre, MD, PhD
“TBD”
Distinguished Lecture Series
Medical College of Wisconsin, Milwaukee, WI
May 3-7, 2020 The Association for Research in Vision and Ophthalmology - ARVO
Annual Meeting
Baltimore, MD
May 2-6, 2021 The Association for Research in Vision and Ophthalmology - ARVO
Annual Meeting
San Francisco, CA
May 1-5, 2022 The Association for Research in Vision and Ophthalmology - ARVO
Annual Meeting
Denver, CO
April 23-27, 2023 The Association for Research in Vision and Ophthalmology - ARVO
Annual Meeting
New Orleans, LA
May 5-9, 2024 The Association for Research in Vision and Ophthalmology - ARVO
Annual Meeting
Seattle, WA
May 4-8, 2025 The Association for Research in Vision and Ophthalmology - ARVO
Annual Meeting
Austin, TX

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