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Research Collaborations - Clinical and Translational Science Institute

The Clinical and Translational Science Institute (CTSI) of Southeast Wisconsin is a consortium of eight Milwaukee institutions working in partnership to cultivate biomedical research as a signature strength of the region while advancing patient care and education.
        
Member institutions are:

  • Medical College of Wisconsin (MCW)
  • Marquette University
  • Milwaukee School of Engineering (MSOE)
  • University of Wisconsin-Milwaukee (UWM)
  • BloodCenter of Wisconsin (BCW)
  • Children's Hospital of Wisconsin (CHW)
  • Froedtert Hospital
  • Zablocki VA Medical Center

In 2013, the CTSI provided support for 66 collaborative research studies.

These studies are conducted by investigators from 16 institutions: Acceleron Pharma, Inc., AIDS Resource Center of Wisconsin, Aurora Healthcare Sinai Hospital, BCW, CHW, Cleveland Clinic, Dryhootch of America, Emory University, Harvard Medical School, Marquette University, MCW, Medical University of S. Carolina, MSOE, UW-Madison, UW-Milwaukee, VA

TITLE OF STUDY

Collaborating Institution

# of Researchers on Study per Institution

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate
the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects with Acute Spinal Cord Injury
MCW3
CHW*1
A Phase 3 Clinical Study to Determine the Safety and Efficacy of rVWF:rFVIII and r VWF in the Treatment and Prevention of Bleeding Episodes in Subjects Diagnosed with von Willebrand DiseaseCHW*3
MCW1
A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Elvitegravir/Cobicistat/ Emtricitabine/Tenofovir Alafenamide Vs Elvitegravir/ Cobicistat/ Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Positive, Antiretroviral Treatment- Naïve AdultsMCW5
ARCW AIDS resource
center of WI
1
A Single Ascending Dose Phase I Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Biologic Activity of Intravenous NKTT120 in Adults with Stable Sickle Cell DiseaseBCW*1
MCW1
A Worldwide, Multicenter, Double-Blind, Randomized, Placebo-Controlled, 12-Week Study to Assess the Efficacy and Tolerability of Anacetrapib When Added to Ongoing Lipid-Lowering Therapy in Adult Patients with Homozygous Familial Hypercholesterolemia (HoFH) with a 52-Week Open-Label ExtensionMCW2
Assessment of the Benefits, Risks, and Costs of Neonatal Screening for Cystic FibrosisCHW*2
UW-Madison1
Assessment of the Contribution of Platelet TFPI to the Severity of Bleeding in Patients with Hemophilia: Phase IIBRI1
CHW2
Brain Activation and the Stress Response during Motor Performance in Older AdultsMCW2
Marquette Univ2
Cell based Model to study dystrophic cardiomyopathyMCW2
CHW1
Deoxyguanosine monophosphate (dGMP) and Deoxyadenosine monophosphate (dAMP) Treatment for DGUOK DeficiencyCHW*1
Univ. S. Carolina1
Development of a prototype, fuzzy logic-based mobile application and web interface for self management of T2DMMCW3
UW-Milwaukee1
MSOE1
Differences in the characteristics of the visceral and subcutaneous adipose tissueMCW8
CHW1
Effect of Adenosine 2A Receptor Agonist Regadenoson on Microvascular Blood Flow in Sickle Cell AnemiaMCW4
CHW1
Effect of early rest on recovery from pediatric concussionCHW*2
MCW1
Effects of Altered Perfusion on Neuromuscular Fatigue and Leg Function Post StrokeMCW1
Marquette Univ1
Fibrocytes in Sickle Cell DiseaseMCW4
CHW4
fMRI Analysis of Working Memory Deficits in Children with Posterior Fossa TumorsMCW2
CHW2
fMRI and Robot-Assisted Practice of Activities of Daily LivingMCW11
UW-Milwaukee1
fMRI and Robot-Assisted Practice of Activities of Daily Living: Case StudiesMCW8
UW-Milwaukee1
fMRI of the Person Identity Network: Aging and APOEMCW3
Marquette Univ1
UW-Milwaukee1
Cleveland Clinic1
Gender differences in the effects of insulin resistance in African Americans plus survey, Factors Affecting AA Participants in Clinical ResearchMCW5
CHW1
Gene Identification of Childhood Kidney DiseaseCHW*5
CHW1
Genetic Analysis Of Children With And Without Inflammatory Bowel Disease (IBD)CHW3
Emory Univ1
Genetic Basis of HemangiomasCHW*2
MCW1
Genetic Modifiers in Cystic FibrosisMCW1
CHW1
Genetic Studies of Human Development DisordersCHW*1
MCW1
GORE HELEX™ Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke or Imaging- Confirmed TIA in Patients with Patent Foramen Ovale (PFOMCW4
CHW1
Human Brain Imaging during LocomotionMarquette Univ6
MCW5
Inflammatory markers, physical fitness, and pain in obese children and adolescentsMarquette Univ4
CHW2
Intestinal Microbiota and the Pathogenesis of Cardiovascular DiseaseMCW5
CHW1
Intrauterine and Perinatal Bisphenol-A and Neonatal Body CompositionCHW*4
UW-Milwaukee1
Mapping the Effects of the KIAA0319 Dyslexia Susceptibility Gene on the Neural Substrates of ReadingMCW3
CHW1
Measuring Body Composition with Spina Bifida: A Pilot StudyCHW3
Marquette Univ1
UW-Milwaukee1
Mechanism and Repository Study (MARS) for the Red Cell Storage Duration StudyMCW3
BCW1
Molecular Variants Causing von Willebrand DiseaseCHW*4
MCW1
Mpex 207: A Phase 3, Multi-Center, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MP 376 (Levofloxacin Inhalation Solution; Aeroquin) in Stable Cystic Fibrosis PatientsCHW*4
MCW1
Mpex 209: A Phase 3, Open-Label, Randomized Trial to Evaluate the Safety and Efficacy of MP-376 Inhalation Solution (Aeroquin) Versus Tobramycin Inhalation Solution (TIS) in Stable Cystic Fibrosis PatientsCHW*4
MCW3
Pathophysiological Mechanisms in Type I vWDCHW*4
MCW1
PREMIUM-Prospective Randomized investigation to Evaluate incidence of headache reduction in subjects with Migraine and PFO Using the AMPLATZER PFO Occluder compared to medical Management. IDE#: G050054MCW5
CHW1
Safety of Adenosine 2AA Agonist Lexiscan in Children and Adults with Sickle Cell DiseaseMCW3
CHW1
Self-management Guided Discharge Teaching for Parents of Hospitalized Children: A Pilot Study (Short title = The Discharge Study)CHW2
Marquette Univ1
UW-Milwaukee2
Stroke with transfusions changing to hydroxyurea (SWiTCH): a phase III randomized clinical trial to compare standard therapy (erythrocyte transfusions with iron chelation) with alternative therapy (hydroxyurea with phlebotomy) for the prevention of secondary stroke and the management of iron overload in pediatric subjects with sickle cell anemia and previous strokeCHW*2
MCW1
The Aging Brain: Imaging Genetics of Brain Structure and FunctionMCW1
UW-Milwaukee1
The effect of combining prebiotic treatment with a diet/physical activity educational program on body composition and intestinal microbiota among predominately overweight and obese childrenMarquette Univ1
CHW2
The Effect of Tailored Step-Count Feedback on Vascular Homeostasis and Cardiovascular Performance in the Patients with and without underlying coronary artery diseaseMCW3
UW-Milwaukee1
"Title: Clinical Study to Identify the Source and Pathogenesis of BK Virus in Renal Transplant Recipients."CHW*4
MCW3
Use of FMRI to Study Brain Activation following Rectal Stimulation in Children with IBDCHW*3
MCW1
Whole Genome SequencingCHW*2
MCW2
Wisconsin Alzheimer’s Disease Research CenterMCW7
UW-Madison1
Wisconsin Pediatric Cardiac Registry:  Consent for Involvement and Participation in Environment and Genetic StudiesCHW*1
MCW1
Assessment of Coupling Between Mass Neural Activity and the Hemodynamic Response in HumansMCW1
Marquette Univ1
Characterizing the Neural Basis of Extinction of Conditioned Fear as the Critical Component Exposure Therapy for PTSDMCW1
UW-Milwaukee4
Design of Immunomudulatory Peptides from the HTLV-2 Tax ProteinMCW4
VA**1
Development of Novel Therapeutics for Triple-Negative Breast CancerMCW5
Effects of Altered Perfusion on Neuromuscular Fatigue and Leg Function Post StrokeMCW1
Marquette Univ2
Highly Sensitive Non-Invasive Method to Monitor Cardiac Transplant RejectionMCW8
Marquette Univ1
Inflammatory Markers, Physical Fitness and Pain in ChildrenCHW1
MCW3
Marquette Univ5
Inhibition of Activin Type IIB Receptor Signaling as a Treatment for Nemaline MyopathyAcceleron Pharma, Inc.1
Harvard1
MCW5
Marquette Univ1
mPeer: Mobile Detection of High Risk Behavior in Veterans- A Sociotechnical Systems ApproachMCW3
Dryhootch of America3
Marquette Univ1
VA**1
Multi-scale pharmacokinetic modeling of imaging biomarkers for assessing acute lung injuryMCW2
Marquette Univ2
New Hypoxia Radiosensitizers as Targeted Anticancer AgentsMCW4
UW-Milwaukee2
Novel Small Molecules to Treat Radiation InjuryMCW2
Parent/Nurse Controlled Analgesia for Post-Operative Pain Management in Neonates: A Preliminary Randomized Controlled TrialCHW1
MCW11
Pilot Intestinal Microbiota and the Pathogenesis of Cardiovascular DiseaseMCW7
Tetrahydrobiopterin in Neonatal Hyperoxic Lung InjuryAurora Healthcare
Sinai Hospital
1
MCW2
Marquette Univ1
Translating iPSCs to study genotype-phenotype correlations of dystrophic cardiomyopathyCHW1
MCW3

* Primary CHW investigator has faculty appointment at MCW
** Primary investigator has joint appointment MCW & VA

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