Biomedical Imaging Shared Resource

The Biomedical Imaging Shared Resource (BISR) supports the advancement of cancer research at the Medical College of Wisconsin Cancer Center (MCWCC) by providing biomedical imaging expertise and technologies to the MCW cancer research community. Specifically the BISR promotes the incorporation of imaging technologies and methods that enable the dynamic assessment of cancer growth, metabolism, and response to therapy with the goal of strengthening both the quality and translational potential of cancer research at MCW.

The overall goal of the BISR is to Drive Cancer Research with state of the art Imaging Technologies.

Educate and train Investigators to incorporate in vivo imaging in their research programs. In particular, advise on:

  • Defining imaging goals: sensitivity or specificity of disease detection, biomarker validation, agent bio-distribution, pharmacokinetics, disease mechanism, drug response etc.

  • Modality selection as per imaging goals

  • Protocol Design and animal models

  • Data acquisition

  • Post-processing, data analysis, archiving, and mining.

  • Leveraging Imaging for Extramural funding.

The major goal of BISR is to strengthen the quality and translational potential of cancer research being performed at MCW through the incorporation of state-of-the-art imaging methods and technologies. 

Cancer Imaging

Ultimately, integrating molecular, functional, and physiological imaging methods more fully into cancer research will enable a better understanding of cancer processes, prognosis, and response to treatment, as well as enhance the information gained from clinical imaging studies. 


  • Co-directed by Amit Joshi, PhD and Peter LaViolette, PhD
  • Contact Dr. Joshi at 414-955-7588 or Dr. LaViolette at 414-456-7490 for more information or to schedule services. 


  • Introduction to potential MCW imaging collaborators (existing imaging expertise)
  • Experimental design consultation (e.g., modality, contrast agent selection)
  • Assistance with IACUC submission (imaging aspects).
  • Routine Data Acquisition        
  • Specialized Data Acquisition (novel pulse sequence development/verification, phantom construction)
  • Data Processing           

Key Equipment


The BISR has access to equipment for  both small animal and human imaging systems fully dedicated tor research purposes. Animal Imaging For high-resolution 3D pre-clinical studies (Fig. 1)  This equipment is supplemented with surgical suites, computing and data storage equipment, and animal holding facilities. Human imaging For scanning research volunteers and clinical volunteers, our campus houses 9 MRI scanners (Fig. 2) for imaging adults and pediatric patients.












Scientific Examples

A unique strength of imaging research at MCW is MRI technology development, which has kept MCW at the forefront of new developments such as functional MRI (fMRI), resting state fMRI, new coil/hardware development and providing seminal contributions in image post-processing. Figures (1,6). Small animal whole body optical imaging expertise is available. This includes fluorescence imaging in visible to NIR range and bioluminescence imaging for tracking therapy response. (Fig. 2-5). Shortwave IR imaging, ultrasound and CT fluoroscopy are also available for collaborations.





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Department of Biophysics
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509

Phone: 414-955-4000

Fax: 414-955-6512

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Page Updated 11/12/2014