MEG vs. EEG?
Today’s MEG commercial systems are organized in whole-head sensor arrays arranged in a rigid helmet covering most of the head surface but the face area. MEG signals are recorded from about 300 channels, which sometimes consist of pairs of magnetometers to form physical gradiometers (Hämäläinen, Hari, Ilmoniemi, Knuutila, & Lounasmaa, 1993). These latter are less sensitive to far-field sources, which are supposed to originate from distant generators (e.g., road traffic, elevators, heartbeats). An important benefit of MEG systems is the possibility to record EEG from dense arrays of electrodes (>60) simultaneously, thereby completing the electromagnetic signature of neural currents.
Additional analog channels are usually available for miscellaneous recordings (heart monitoring (ECG), muscle activity (EMG), eye movements (EOG), respiration, skin conductance, subject’s responses, etc.). Sampling rate can reach up to 5KHz on all channels with a typical instrumental noise level limited to a few fT/sqrt(Hz). One femto-Tesla (1fT) is 10-15T. Ongoing brain signals measured with MEG are on the range of about [10,50] fT/sqrt(Hz), with a relatively rapid decay in amplitude as frequency increases.
MEG has substantial benefits with respect to EEG:
while EEG is strongly degraded by the heterogeneity in conductivity within head tissues (e.g., insulating skull vs. conducting scalp), this effect is extremely limited in MEG, resulting in greater spatial discrimination of neural contributions. This has important implications for source modeling as we shall see below;
Subject preparation time is reduced considerably;
Measures are absolute, i.e. they are not dependent on the choice of a reference;
Subject’s comfort is improved as there is no direct contact of the sensors on the skin.
MEG/EEG experiments can be run with the subjects in supine or seated positions. A caveat however concerns EEG recording in supine position, which may rapidly lead to subject discomfort because occipital electrodes become painful pressure points. The quiet, room-size and fairly open environment of the MSR and Faraday cages (relatively to MRI bores), make it more friendly to most subjects. Care givers may accompany subjects during the experiment.
Installation of new MEG systems is presently steadily growing within research and clinical centers (about 200 worldwide).
On the benefits of a larger number of sensors: (a) 3D rendering of a subject’s scalp surface with crosshair markers representing the locations of 151 axial gradiometers as MEG sensors (coil locations are from the VSM MedTech 151 Omega System). (b) Interpolated field topography onto the scalp surface 50 ms following the electric stimulation of the right index finger. The fields reveal a strong and focal dipolar structure above the contralateral central cortex. (c) The number of channels has been evenly reduced to 27. Though the dipolar pattern is still detected, its spatial extension is more smeared – hence the intrinsic spatial resolution of the measurements has been degraded – due to the effect of interpolation between sensors, which are now quite distant from the maxima of the evoked magnetic field pattern.
Froedtert & The Medical College of Wisconsin MEG Contact Information
Research investigators and clinical physicians are encouraged to contact us for further information on how to access our MEG Program and services.
Zhimin Li, PhD: Technical Manager
Jean Roccapalumba, CTRS, MBA: Program Manager
Department of Neurology
Medical College of Wisconsin
9200 W. Wisconsin Ave.
Milwaukee, WI 53226
MEG Program Site Map
If you are a physician and would like to inquire about or order a MEG study for your patients, please visit Froedtert Hospital MEG web pages for basic information about the procedure and/or contact Linda Allen, RN BSN, our Epilepsy Program Coordinator at (414) 805-3641 to refer your patient to our Program.
If you are a patient who is about to undergo an MEG procedure, please also visit Froedtert Hospital MEG web pages for useful information regarding the MEG routine.