MCW Research News – Basic Sciences

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Dr. Everson Discovers that Sleep Deprivation Causes Cellular Damage

Dec. 15 - Carol Everson, PhD is lead author of a study published in Sleep that found that sleep deprivation causes damage to cells, especially in the liver, lung, and small intestine. Medical News Today and Milwaukee Courier

MSTP Student Receives $180,000 NIH Grant to Study Development of Diabetes

Dec. 9 - Zach Shaheen, an MCW Medical Scientist Training Program (MSTP) student, received a four-year, $180,000 National Institute of Diabetes and Digestive and Kidney Diseases grant to investigate the pancreatic immune response involved in the development of insulin-dependent diabetes mellitus during a viral infection. MSTP students are enrolled in both MCW’s Medical School and Graduate School. Wauwatosa Now

MCW researchers find link between sleep deprivation and cell damage

Dec. 8 - Scientists at the Medical College of Wisconsin (MCW) have discovered a link between sleep loss and cell injury. Results of a new study find sleep deprivation causes the damage to cells, especially in the liver, lung, and small intestine. Recovery sleep following deprivation heals the damage.

NASA funds research into heart disease risks from space radiation

Dec. 5 - NASA has awarded John Baker, PhD, professor of cardiothoracic surgery and biochemistry at MCW, a five-year, $1.8 million grant to research the impact of cosmic radiation on astronauts’ cardiovascular health. Milwaukee Journal Sentinel

Opinion editorial: NIH needs funding to fight Ebola and other diseases

Nov. 20 - Dr. John R. Raymond, Sr., and Dr. Robert Golden, Dean of the UW School of Medicine & Public Health, co-authored an opinion editorial in the Wisconsin State Journal calling on Congress to approve funding for the National Institutes of Health for the new federal fiscal year that began on October 1. Wisconsin State Journal

Nature Reports on Dr. Brandow’s Research on Sickle Cell Disease Nerve Damage

Nov. 17 - Nature reports on Dr. Amanda Brandow’s research on sickle cell disease nerve damage. Nature

Congress Needs to Approve NIH Budget

Nov. 11 - Dr. John R. Raymond, Sr., and Dr. Robert Golden, Dean of the UW School of Medicine & Public Health, co-authored an opinion editorial in the Wisconsin State Journal calling on Congress to approve funding for the National Institutes of Health for the new federal fiscal year that began on October 1. Wisconsin State Journal

MCW scientist to investigate mediators of sickle cell disease pain

Nov. 11 - Katherine Zappia, a graduate student at the Medical College of Wisconsin has received a two-year, $85,000 fellowship from the Department of Health and Human Services’ National Institute of Neurological Disorders and Stroke to investigate the mediators contributing to the pain experienced in sickle cell disease.

Researcher to investigate Leptospira

Nov. 6 - Jenifer Coburn, PhD has been awarded an NIH grant to study the mechanisms of leptospira bacteria. Wauwatosa Now

MCW researcher to investigate leptospira bacteria

Oct. 27 - The Medical College of Wisconsin has received a two-year, $420,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to advance the understanding of leptospirosis, a serious bacterial infection affecting humans and animals, and how it establishes persistent infection in the kidney.

Dr. Klug Receives $1.2 Million NIH Grant to Advance Understanding of Endotoxin

Oct.14 - Candice Klug, PhD received a four-year, $1.2 million grant from the National Institute of General Medical Sciences to advance the understanding of how endotoxin, a major component of disease-causing bacteria, is transported within the cell. Wauwatosa Now

Center for Imaging Research seeks grant applications

Oct. 2 - The Center for Imaging Research seeks grant applications to provide vital funding for innovative imaging-based research projects at the 3T and 7T scanners. The Center will issue five $5,000 and five $15,000 awards to be used for MRI scanner fees and applicable subject stipends and transportation costs.

Can you prevent diabetes?

Oct. 10 - A collaborative team of researchers from the Medical College of Wisconsin (MCW) and the Milwaukee School of Engineering has received a one-year, $50,000 grant from the Clinical and Translational Science Institute of Southeast Wisconsin (CTSI) to study possible interventions to prevent the development of type 1 diabetes (T1D).

Drug mitigates early Parkinson’s symptoms in mouse model

Oct. 9 - A team of researchers has shown that long-term administration of a novel drug to mice exhibiting Parkinson’s disease-like symptoms is effective in mitigating loss of smell, improving motor coordination and preventing the tendency to fall – all early symptoms of Parkinson’s disease. A manuscript highlighting these findings has been accepted for publication in the journal, Neuroscience Letters.

MCW researcher receives funding from new “Big Data to Knowledge” initiative

Oct. 9 - The Medical College of Wisconsin (MCW) has received a five-year, $500,000 training grant from the National Institutes of Health’s (NIH) National Institute of Environmental Health Sciences to investigate the development of a tool to interpret the genetic data of humans affected with cardiovascular disease.

Dr. Coburn Receives $1.5 Million NIH Grant to Advance Understanding of Leptospirosis

Jenifer Coburn, PhD received a four-year, $1.5 million grant from the National Institute of Allergy and Infectious Diseases to advance the understanding of leptospirosis, a serious bacterial infection affecting humans and animals worldwide. Wauwatosa Now

MCW Researcher to Investigate Bacterial Endotoxin

Oct. 7 - The Medical College of Wisconsin (MCW) has received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to advance the understanding of how endotoxin, a major component of disease-causing bacteria, is transported within the cell.

MCW researcher to investigate the bacterial-host interactions in leptospirosis

Oct. 2 - The Medical College of Wisconsin has received a four-year, $1.5 million grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to advance the understanding of leptospirosis, a serious bacterial infection affecting humans and animals worldwide.

Dr. Beyer Receives Office of the NIH Director Grant to Study Novel Disease Models

Oct. 1 - Andreas Beyer, PhD is principal investigator of a two-year, $470,000 grant from the Office of the Director of the NIH to generate and characterize novel disease models of use for the greater scientific community. Wauwatosa Now

Drs. Sengupta and Banerjee Receive $1.8 Million NIH Grant to Study Chronic Pelvic Pain

Sept. 30 - Jyoti Sengupta, PhD, and Banani Banerjee, PhD, (both Medicine – Gastroenterology and Hepatology) will serve as the primary investigators of a four-year, $1.8 million National Diabetes and Digestive and Kidney Diseases grant to study the genetic and physical causes of chronic pelvic pain. Becker's ASC Review and Biz Times

Scientist receives NIH Director’s Award to study molecular causes of disease

Sept. 23 - The Medical College of Wisconsin has received a two-year, $470,000 exploratory grant from the Office of the Director of the National Institutes of Health to generate and characterize novel disease models of use for the greater scientific community.

Dr. Woods Identifies New Gene Associated with Traits Involved in Diabetes

Sept. 22 - In a study published in Genetics, Leah Solberg Woods, PhD and colleagues reported that they had has identified a new gene associated with fasting glucose and insulin levels in rats, mice and in humans; traits involved in diabetes. Nature World News, Health Canal, Medical Xpress and Bio-Medicine

Drs. Volkman and Grayson Receive NIH Grant to Identify New Therapeutic Targets for COPD

Sept. 15 - Brian Volkman, PhD and Dr. Mitchell Grayson are co-primary investigators of a one-year, $382,500 grant from the National Institute of Allergy and Infectious Diseases to identify new therapeutic targets for chronic obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. Biz Times

MCW resident awarded NIH loan repayment grant

Sept. 05 - Mohamed Algahim, MD, a resident in the integrated cardiothoracic surgery program at MCW, has been awarded a loan repayment grant from the National Institutes of Health (NIH).

MCW scientists to investigate new therapy for obstructive lung disease

Sept. 04 - The Medical College of Wisconsin has received a one year, $382,500 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to identify new therapeutic targets for chronic obstructive lung diseases such as asthma and chronic obstructive pulmonary disease.

The Role of MicroRNA’s in High Blood Pressure

Aug. 26 - The Medical College of Wisconsin has received a four year, $1.5 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to study the role of a specific microRNA in the development of hypertension and associated kidney injury.

Dr. Sorokin Receives NCI Grant to Evaluate New Pathway for Inhibiting Cancer Cell Growth

Aug. 04 - Andrey Sorokin. PhD received a two-year, $153,000 grant from the National Cancer Institute to evaluate COX-2 regulation as a potential new pathway for inhibiting the growth of cancer cells. Wauwatosa Now

Spinal cord injury: what determines recovery?

The Medical College of Wisconsin (MCW) has received a two year, $300,000 grant from the Craig H. Neilsen Foundation for Spinal Cord Injury Research to study better recovery and care for spinal cord injury patients.

$2.6 Million NIH Grant Awarded to Study New Treatment Approaches for Pancreatic Cancer

Michael Dwinell, PhD and Balaraman Kalyanaraman, PhD received a five-year, $2.6 million grant from the National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer. Wauwatosa Now

Researchers to explore new treatments for pancreatic cancer

The Medical College of Wisconsin has received a five-year, $2.6 million grant from the National Institutes of Health’s National Cancer Institute to study new therapeutic approaches to treat pancreatic cancer.

Dr. Stoner Discusses Study on Cancer-Fighting Qualities of Broccoli-Sprout Tea

July 17 - Gary Stoner, PhD provides expert comment to a Pittsburgh Post-Gazette article on a University of Pittsburgh School of Medicine study that found that broccoli-sprout tea helps purge the body of air-pollution toxins, including carcinogenic benzene. Pittsburgh Post Gazette

Protein Foundry, a new company, launches at MCW

July 11 - Protein Foundry, a new company manufacturing and marketing protein molecules, had its official launch Thursday, July 10, at the Medical College of Wisconsin.

Dr. Bai Receives $1.4 Million NIH Grant to Study Impact of Anesthesia on Children

July 07 - Dr. Xiaowen Bai received a five-year, $1.4 million grant from the National Institute of General Medical Sciences to determine the role of microRNAs in damage to the nervous system in some children and fetuses that have been exposed to anesthetic. Wauwatosa Now

How safe is anesthesia for children?

July 02 - The Medical College of Wisconsin has received a five-year, $1.4 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to determine the role of microRNAs in damage to the nervous system in some children and fetuses who have been exposed to anesthetic.

Dr. Siegel Receives $1.3 Million Grant to Study Genetic Causes of PHACE Syndrome

June 30 - Dr. Dawn Siegel received a three-year, $1.3 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to study the genetic causes of PHACE syndrome, which is characterized by a large facial hemangioma with other birth defects including abnormalities of the brain, heart, and eyes. Wauwatosa Now

NIH Awards $2.6 Million Grant to Study Effects of Stress in Drug Addiction Relapse

June 30 - Cecilia Hillard, PhD is co-principal investigator of a $2.6 million NIH grant awarded to John Mantsch, PhD, of Marquette University. The joint MCW/Marquette study will investigate the effects of stress in drug addiction relapse. Milwaukee Journal Sentinel and GM Today

Glaucoma Research Foundation funds research at MCW

June 26 - The Medical College of Wisconsin and three other collaborators have received a three-year, $750,000 grant each from the Glaucoma Research Foundation to study biomarkers that may indicate early signs of glaucoma.

Dr. Everson Links Insufficient Sleep to Onset of Osteoporosis

June 24 - Carol Everson, PhD is lead author of a study reported in Experimental Biology and Medicine that links insufficient sleep to the onset of osteoporosis and a lessened ability to repair slight bone damage caused by normal everyday activity. Canada Drug Center

Drug addiction: what causes relapse?

June 24 - Researchers at MCW and Marquette University have earned a five-year grant to study addiction: cravings, relapse, and stress. Cecilia Hillard, PhD, professor of pharmacology and toxicology and director of the Neuroscience Research Center at MCW, is a co-PI on the grant. Milwaukee Journal Sentinel

Researcher to study relationship between nervous system cells and blood flow in brain

June 17 - The Medical College of Wisconsin (MCW) has received a four-year, $1.5 million grant from the National Institutes of Health’s (NIH) National Heart, Lung, and Blood Institute to study how astrocytes, the cells that support neurons in the brain and spinal cord, affect the genetic makeup and function of other cells in the brain.

Exploring new methods to treat drug addiction

June 12 - The Medical College of Wisconsin has received a five-year, $1.6 million grant from the National Institutes of Health’s National Institute on Drug Abuse to study the mechanisms by which phosphodiesterase inhibitors reduce addictive behaviors.

Dr. Jackson Receives $2.2 Million NIH Grant to Study How Viruses Become Infectious

June 10 - William Jackson, PhD received a five-year, $2.2 million grant from the National Institute of Allergy and Infectious Disease to study the ways in which specific viruses become infectious. Wauwatosa Now

Researcher to study the conversion from harmless viral particles to disease-causing viruses

June 04 - The Medical College of Wisconsin has received a five-year, $2.2 million grant from the National Institutes of Health’s National Institute of Allergy and Infectious Disease to study the ways in which specific viruses become infectious.

NCAA and DoD launch $30M concussion initiative; MCW will lead advanced research core

May 29 - The Medical College of Wisconsin has been selected to lead the research core in the most comprehensive study of concussion and head impact exposure in sports ever conducted.

College, Medical Center Team to Recognize VA Research Week

May 29 - MCW and the Zablocki VA Medical Center teamed to recognize VA Research Week. Wauwatosa Now

Improved transportation safety: collaboration with VA

May 21 - Transportation crashes, unfortunately, are a fact of life. Faculty and staff in the Vehicle Crashworthiness Laboratory and the Neurosurgery Research Facility at the Clement J. Zablocki VA Medical Center use their biomedical engineering expertise to minimize the effect crashes have on the people involved.

Brain and spinal cord Injury research programs at VA

May 22 - The Medical College of Wisconsin and the Clement J. Zablocki VA Medical Center are collaborating to improve the lives of those with brain and spinal cord injuries.

Researcher awarded $1.02 million grant for spinal cord injury research

May 22 - The Medical College of Wisconsin has received a four-year, $1.02 million grant from the Department of Veterans Affairs Rehabilitation Research and Development Division for spinal cord injury research.

Dr. Stucky Receives $1.9 Million NIH Grant to Study Causes of Sickle Cell Disease Pain

May 21 - Cheryl Stucky, PhD received a five-year, $1.9 million grant from the National Institute of Neurological Disorders and Stroke to study the underlying causes of pain in sickle cell disease. WauwatosaNOW

Why does sickle cell hurt? Researcher to study pain of the disease

May 14 - The Medical College of Wisconsin has received a five-year, $1.9 million grant from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke to study the underlying causes of pain in sickle cell disease.

Dr. Lombard receives NIH Director’s award to investigate antioxidants

May 13 - Julian Lombard, PhD received a two-year, $420,000 exploratory grant from the Director’s Office of the National Institutes of Health to investigate antioxidants and why direct administration of antioxidants for human disease have not been more successful. WauwatosaNOW

Dr. Malarkannan receives $1.6 million NCI grant to develop cell-based cancer therapies

May 13 - Subramaniam Malarkannan, PhD received a five-year, $1.6 million grant from the National Cancer Institute to support development of novel immune cell-based therapies to cancer. Biz Times

Researchers to study naturally-occurring antioxidant

May 12 - The Medical College of Wisconsin has received a two-year, $420,000 exploratory grant from the Director’s Office of the National Institutes of Health to investigate antioxidants and why direct administration of antioxidants for human disease have not been more successful.

Alumni/Students/Patients in Wisconsin

Wisconsin map of Alumni, Students and Patients

MCW receives National Cancer Institute grant to develop novel cellular immunotherapy

May 07 - The Medical College of Wisconsin has received a five-year, $1.6 million grant from the National Institutes of Health’s National Cancer Institute to support development of novel immune cell-based therapies to cancer.

Dr. Scaglione Receives $740,000 NIH Grant to Study How Neurons Clear Toxic Proteins

May 06 - Matthew Scaglione, PhD received a three-year, $740,000 grant from the National Institute of Neurological Disorders to investigate how neurons clear toxic proteins involved in neurodegenerative disease. Biz Times

MCW research team author paper in Nature on touch perception

May 06 - Cheryl Stucky, PhD, Professor of Cell Biology, Neurobiology and Anatomy, and Andy Weyer, Research Assistant in Dr. Stucky’s lab, have published a paper in Nature on touch perception.

Dr. Corbett Receives $1.4 Million NIH Grant to Study Cell Death Leading to Diabetes

May 05 - John Corbett, PhD received a four-year, $1.4 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases to study what causes destruction of the cells that produce insulin in the body, leading to diabetes. Milwaukee Journal Sentinel

Craig Nielsen Foundation awards $300,000 grant to MCW for spinal cord injury research

May 02 - Researchers in the Department of Neurosurgery were awarded a two-year, $300,000 grant from the Craig Nielsen Foundation for Spinal Cord Injury Research.

Cancer Center announces pilot grant awards

April 30 - Seed grants are critical to the future of cancer research, and provide investigators with initial backing to further their science, collect data, publish, and secure NIH funding.

MCW receives grant supporting research in neurodegenerative disease

April 30 - The Medical College of Wisconsin has received a three-year, $740,000 grant from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke funding research investigating how neurons clear toxic proteins involved in neurodegenerative disease.

MCW researcher to study mechanisms involved in diabetes

April 30 - The Medical College of Wisconsin (MCW) has received a four-year, $1.4 million grant from the National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to study the biochemical causes of beta cell destruction in diabetes.

The Role of Viruses in Diabetes

April 28 - The Medical College of Wisconsin has received a five-year, $1.9 million grant to study the role of viruses in pancreatic beta cell damage in diabetes.

Dr. Lawlor Discusses Research on Rare Genetic Muscular Disorder

Apr 22 - NBC-TV/Channel 4 reported on research being conducted by Dr. Michael Lawlor on Myotubular Myopathy, a rare genetic muscular disorder. WTMJ-TV

Family holds out hope for a cure for a rare genetic disorder

Apr 10 - Research at the Children’s Hospital of Wisconsin Research Institute and MCW is providing hope for families with children with rare muscular disease. WTMJ-TV

TOPS Club Commits $205,000 for Obesity Research

Apr 8 - TOPS Club, Inc., a Milwaukee-based weight loss organization, has committed $205,000 toward MCW research obesity and metabolic disorders. BizTimes

Dr. Stucky and Scripps Colleagues Identify Factors Creating Sensation of Touch

Apr 8 - Cheryl Stucky, PhD, and collaborators at the Scripps Research Institute published a study in Nature that identified a dual-sensor system involving the Merkel cell and an associated nerve end that contribute to the touch sensation. Medical Express

Dr. Prokop Co-Authors Study on the Discovery of a Missing Hormone in Birds

Apr 3 - Jeremy Prokop, PhD, collaborated with lead authors at the University of Akron who were the first to discover leptin in birds. BrightSurf.com

Dr. Duncan Provides Comment on New Process to Shortcut Skin-to-Liver Cell Reprogramming

Feb 25 - Stephen Duncan, PhD, provides expert comment in The Scientist on a research study reported in Nature that researchers at University of California San Francisco have adapted a reprogramming technique that speeds the process of converting skin cells to liver cells. The Scientist

Understanding bacteria’s resistance to antibiotics may lead to better treatments

Feb. 21 - The Medical College of Wisconsin (MCW) has received a two-year $378,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to study the mechanisms underlying drug resistance in bacteria.

Gut studies hold promise for prevention

Medical College of Wisconsin researchers are studying intestinal bacteria as a promising new approach for the prevention of heart attacks and a range of other conditions, including pediatric liver disease and antibiotic-resistant, hospital-acquired infections.

Graduate student aims at brain research

Using technology and tools that the Medical College of Wisconsin was a world leader in developing, a PhD student in the Graduate School of Biomedical Sciences and her faculty mentor are pursuing brain research with potential to benefit cancer patients.

Genetics team to create hundreds of new knockout rats to study human disease

Feb. 13 - The Medical College of Wisconsin has received a five-year, $8.7 million grant from the National Institutes of Health’s National Heart, Lung and Blood Institute to create 200 gene-targeted rat models to study the genetics of human disease.

Dr. Kim Receives $1.2 Million NIH Grant to Study How the Body Metabolizes Drugs

Feb 12 - Jung-Ja Kim, PhD, received a four-year, $1.2 million grant from the National Institute of General Medical Sciences to study the way in which the human body metabolizes drugs, and the causes behind abnormal steroid hormone production. WauwatosaNOW

Researchers Find Two Distinct Patterns of Genetic Alteration in Invasive Bladder Cancer

Feb 6 - MCW researchers are co-authors of a Roswell Park Cancer Institute-led study reported in the Proceedings of the National Academy of Sciences that found that invasive bladder cancers demonstrate two distinct patterns of genetic alteration, one of which may result from defects in cells' ability to replicate. Medical News Today

Researcher to investigate mechanics of drug metabolism

Feb. 03 - The Medical College of Wisconsin (MCW) has received a four-year, $1.2 million grant from the National Institutes of Health’s National Institute of General Medical Sciences to study the way in which the human body metabolizes drugs, and the causes behind abnormal steroid hormone production.

Pioneering eye care benefits generations

A landmark advance more than 35 years ago has improved vision dramatically for thousands of patients with diabetic eye disease. Today, vision research at the Froedtert & the Medical College of Wisconsin Eye Institute seeks to actually prevent retinal eye disease.

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Page Updated 10/05/2014
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