Milan Joksimovic, PhD
Medical College of Wisconsin
Department of Cell Biology, Neurobiology & Anatomy
8701 Watertown Plank Road
Milwaukee, WI 53226-3548
(414) 955-6517 (fax)
BS, University of Belgrade, Serbia
PhD, Iowa State University, Ames, IA
Postdoctoral, Northwestern University, Chicago, IL
Positions are currently available for PhD students and Postdoctoral Fellows.
Please contact Dr. Milan Joksimovic at firstname.lastname@example.org or visit our Postdoctoral Positions web page.
Molecular mechanisms governing development of the mammalian central nervous system
A basic question in developmental neurobiology is how a common pool of neural progenitors differentiates into disparate neuronal cell types that are, with an astonishing precision, integrated into functional neural circuits. The midbrain dopamine neurons (mDA) are an attractive system to address this fundamental question. These neurons are implicated in circuits relevant to emotional, cognitive and motor functions. Aberrant function of mDA underlies a broad spectrum of disorders including Parkinson’s disease.
To comprehend mDA related diseases and potentially generate successful therapeutics, it is crucial to decipher molecular mechanisms behind proliferation, cell fate specification, migration, and correct axonal projections of mDA. In an attempt to provide answers to some of these basic questions, my laboratory uses conditional mouse genetics, genetic fate mapping, and various molecular biology techniques.