Allison D. Ebert, PhD

Allison D. Ebert, PhDAssistant Professor

Medical College of Wisconsin
Department of Cell Biology, Neurobiology & Anatomy
8701 Watertown Plank Road
Milwaukee, WI 53226-3548

(414) 955-2979
(414) 955-6517 (fax)
aebert@mcw.edu

PhD, Northwestern University, Chicago, 2005
BS, Indiana University, Bloomington, 1999

Research Area

Parkinson’s Disease, Huntington’s Disease, Spinal Muscular Atrophy, therapeutic uses of stem cells and disease modeling

neurons differentiated from human embryonic stem cells

neurons differentiated from human embryonic stem cells

My research interests are in the area of neurodegenerative diseases, both understanding the molecular basis for the disease progression and finding effective experimental therapies. My current research focuses on using induced pluripotent stem cells (iPSCs) derived from patient tissue to understand disease mechanisms and therapeutic intervention. Specifically, my lab is investigating the cell death processes involved in motor neuron loss in spinal muscular atrophy (SMA). We are using iPSCs derived from an SMA patient to generate motor neurons, astrocytes, and muscle cells to determine how the motor neurons are dying and whether the astrocytes and muscle cells are contributing to the disease process. My lab is also testing the therapeutic potential of ex vivo gene therapy in animal models of Parkinson’s and Huntington’s diseases by transplanting neural stem cells engineered to produce specific growth factors known to aid neuron survival. The growth factors I am actively examining are glial cell line-derivedneurotrophic factor (GDNF), insulin like growth factor (IGF-1), brain derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF). Finally, we are interested in characterizing and understanding survival, migration, and differentiation patterns of transplanted stem cells in models of disease, which could have important clinical relevance.

Recent Publications


Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
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