Gutterman Lab Members

David D. Gutterman, MD

David Gutterman, MD

Principal Investigator, Senior Associate Director of the Cardiovascular Center, Northwestern Mutual Professor in Cardiology

Dr. Gutterman is actively involved in clinical practice, supervises a NIH funded research laboratory and provides senior administrative oversight of research administration at the Medical College of Wisconsin. He has served in a leadership role in a variety of national and international cardiovascular scientific organizations.

dgutt@mcw.edu

Joe Hockenberry, MCW CVC Gutterman Lab

Joe Hockenberry

Research Technologist II

Within Dr. Gutterman’s lab my primary role is to collect and analyze experimental data for multiple research projects and to provide support where needed to meet the goals of the laboratory faculty. I have background in cell biology and regenerative medicine and an interest in genetics and physiology.

jhockenberry@mcw.edu

 

Julie Freed, MD, PhD, MCW CVC Gutterman Lab

Julie Freed, MD, PhD

Post-Doc

Within the theme of the Gutterman lab, my interests include understanding the role of the endothelium in vascular health and disease. My current research looks into how biologically active lipids, specifically sphingolipids which are known to be elevated in patients with coronary artery disease, can signal to the mitochondria and alter the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide. I have also recently become interested in the role of endothelial microparticles in vascular dysfunction.

jfreed@mcw.edu

Ryan Nord, MCW CVC Gutterman Lab

Ryan Nord

Research Technologist I

Dr. David Gutterman’s lab uses discarded surgical tissue for functional vessel studies and I am in charge of all the tissue collection related to this research and maintain a database of all the samples collected. I also make various solutions used in these studies and perform many general lab tasks to help the other lab members meet their research goals.

rnord@mcw.edu


Matt Durand, MCW CVC Gutterman Lab

Matt Durand

Post-Doc

My research interests examine how acute and chronic stress can alter human vascular function.  Using isolated human adipose arterioles, we have shown that increasing intraluminal pressure within the vessel can acutely impair vasodilator responses to acetylcholine and shear stress. This impairment can be reversed in the presence of renin-angiotensin system inhibitors, suggesting that the vascular renin-angiotensin system plays a role in this response. Another study I’m involved with is a collaboration with Marquette University, which examines differential responses to exercise in the femoral artery of people who have suffered a hemiparetic stroke. Preliminary data from this study suggests that decreased blood flow to the paretic leg contributes to baseline muscle weakness and increased neuromuscular fatigability in these individuals.

mdurand@mcw.edu

David Chabowski, MCW CVC Gutterman Lab

David Chabowski

Graduate Student

As a graduate student in Dr. Gutterman’s lab, I am interested in endothelium-independent vascular pathophysiology. Currently, my focus lays in the area of ion channel-mediated hyperpolarization and relaxation of vascular smooth muscle cells in the microcirculation which is critical in regulating myocardial perfusion. Using canulated vessels in combination with electrophysiological and molecular techniques, I plan to examine the role coronary artery disease (CAD) has in modulating voltage-activated potassium channel-mediated hyperpolarization of vascular smooth muscle cells and dilation of resistant coronary arterioles.

dchabowski@mcw.edu


Natalya Zinkevich, PhD, MCW CVC Gutterman Lab

Natalya Zinkevich, PhD

Research Scientist I

My research interests are related to vascular health and disease. Specifically, I am interested in the role of endothelial cells in mediating vasodilation. Within this broad topic, I address three questions:

  1. How do the mechanisms of endothelium-dependent dilation change during aging and with the onset of coronary artery disease?
  2. What is the role of cellular enzymatic sources of reactive oxygen species in this process?
  3. How does the transient receptor potential vanilloid 4 (TRPV4) channel superfamily contributes to vasorelaxation?

nzinkevi@mcw.edu

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