Michael Harrison, MD, PhD
My current projects in the Geurts Lab are using gene-editing technologies to develop the first tissue-specific, conditional gene knockout rat. This project will not only serve as a blueprint for a new generation of sophisticated animal models of disease, but will also be a useful model for understanding cardiovascular disease. My other project involves the creation and testing of new molecules based on zinc-finger and TAL Effector proteins that can target and methylate CpG dinucleotides in specific regions of the genome. The ability to alter the epigenome of target organisms can greatly enhance our understanding of this disease-related mechanism. My main interests are in the field of hypertension, the genetics of complex disease, the development of animal models, and how epigenetics relates to disease.