Elizabeth Rogers Jacobs, MD

Professor and Associate Dean of Research, MCW
Associate Chief of Staff, Research and Development, Zablocki VA Medical Center


(414) 384-2000 x41430
ejacobs@mcw.edu

Elizabeth Rogers Jacobs, MD

Research and Professional Experience

  • 1977–1980 | Internship and Residency, University of Kansas School of Medicine, Internal Medicine
  • 1980–1982 | Fellowship, Univ. of Arkansas Health Science Center, Pulmonary and Critical Care Medicine
  • 1982–1984 | Assistant Professor, University of Oklahoma Health Science Center, Medicine
  • 1984–1987 | Assistant Professor and Director of Research, Rush-Presbyterian-St. Luke’s Medical Center
  • 1984–1989 | Electrophysiologic Research and Training, Rush-Presbyterian-St. Luke’s Medical Center
  • 1987–1989 | Co-Director, Patch Clamp Center, Rush-Presbyterian-St. Luke’s Medical Center
  • 1989–1999 | Associate Professor of Medicine and Physiology, Medical College of Wisconsin
  • 1999 to present | Professor of Medicine and Physiology
  • 2000 to present | Associate Director, Cardiovascular Research Center, Medical College Wisconsin
  • 2001 to present | Division Director, Pulmonary and Critical Care Medicine
  • 2004 to present | Co-director Translational Research Center, Medical College of Wisconsin

Selected Awards And Other Professional Activities

  • Grant review committee for Chicago Heart Association | 1985–1989
  • Co-Chairman, Program Committee for Chicago Lung Association-sponsored Markfield Conference | October 1989; Chair, 1998 to present.
  • Medical Student Honors Thesis Committee MCW member | 1994 to present.
  • Chair, Faculty Development Committee, Department of Medicine, MCW | 1998–2002.
  • Member Rank and Tenure Committee Medical College of Wisconsin | 2002 to present.
  • Ad hoc reviewer, SBIR and SBTIR scientific review group | March 2000; February 2001; October 2003.
  • Member Research Committee, Northern Affiliate American Heart Association | 2000 to present.
  • Consulting Editor, American Journal Physiology: Heart | 2000–2005.
  • Member Research Committee, Wisconsin Lung Association | 2001 to present.
  • Member Respiratory and Integrative Biology and Translational Research NIH Study section | 2004 to present.

Research Projects

  • Lipid Modulators of Pulmonary Vascular Tone.
    Studies role of cyp450s in mediating VEGF and NO induced changes in pulmonary vascular tone.
     
  • Mechanisms of High Flow Induced Vasculopathy.
    The aims of this proposal are to examine the cellular and ionic mechanisms which underlie flow induced vasculopathy localized to the left lower lobe of the lung in juvenile pigs.
     
  • Molecular and Cellular Mechanisms Regulating Pressure-Dependent Autoregulation of Microvascular Blood Flow.

Selected Publications

  • Jacobs ER, Daling Zhu, Stephanie Gruenloh, Bernardo Lopez, Meetha Medhora. VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P450 hydroxylase. In press, American Journal of Physiology: Lung cellular and Molecular Physiology, 2006, 291:L36-L77.
     
  • Yuenmu Chen, Meetha Medhora, John R. Falck, Kirkwood A. Pritchard Jr., Elizabeth R. Jacobs. Mechanisms of activation of eNOS by 20-hydroxyeicosatetraenoic acid and VEGF in bovine pulmonary artery endothelial cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2006, 291:L378-L385.
     
  • Anuradha Dhanasekaran, Rula Al-Saghir, Bernardo Lopez, Ying Gao, David D Gutterman, Elizabeth R. Jacobs and Meetha Medhora: Protective Effects of Epoxyeicosatrienoic acids (EETs) on Human Endothelial Cells from the Pulmonary and Coronary Vasculature. American Journal of Physiology: Heart Circ. Physiol., 2006, 291:H517-H531.
     
  • Dunn LK, Gruenloh SK, Dunn BE, Reddy DS, Falck JR, Jacobs ER and Medhora M:Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). Anatomical Records A Discov Mol Cell Evol Biol. 285(2):771-80, 2005.
     
  • Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER and Harder DR: Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. American Journal of Physiology - Heart & Circ. Physiol. 2003, 284:H215-H224.

Publications as listed in PubMed

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