Vascular biology with a focus on human coronary vascular function.
Effect of disease on arteriolar dilation ability integrating the role of oxygen radicals and other reactive species in modulating dilation both at the endothelial & smooth muscle levels.
Major interest in the mechanisms of dilation especially as they relate to endothelial derived hyperpolarization factors.
Dr. Gutterman is the Northwestern Mutual Professor of Cardiology. He is involved actively in clinical practice, supervises an NIH funded research laboratory, and provides senior administrative oversight of research administration at the Medical College of Wisconsin.
He has served in a leadership role in a variety of national and international cardiovascular scientific organizations. He is the president elect of the American College of Chest Physicians, has served as chair of the American Physiological Society’s Cardiovascular Section, and recently completed a term as chair of the American Heart Association Scientific Publishing Committee. Dr. Gutterman is the Senior Associate Dean for Research at the Medical College of Wisconsin.
He received an MD degree from the University of North Carolina, and completed residency training in internal medicine and fellowship in cardiology at the University of Iowa where he joined the faculty in 1987. Dr. Gutterman was promoted to Professor of Medicine in 1998 prior to moving to the Medical College of Wisconsin.
Dr. Gutterman’s investigative interests focus on regulation of human vascular reactivity both at the fundamental and translational research levels. His work has defined a novel mechanism whereby reactive oxygen species and arachidonic acid metabolites mediate flow-induced dilation in the human coronary microcirculation. His research efforts span basic and clinical science related to vascular health and disease. His laboratory is one of only two world-wide that examines the ability of small blood vessels to control blood flow to the heart of humans.
Dr. Gutterman has also undertaken studies to examine the earliest changes that occur in the development of atherosclerosis (clinical endothelium dysfunction) and has used this technique to examine the beneficial and detrimental roles of various exercise regimens and of dieting on cardiovascular health.
Dr. Gutterman has authored more than 100 articles and reviews related to cardiovascular function and pathophysiology.